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Amazing Ginger Health Benefits
Ginger is one of the most used spices in the world today. In addition to flavoring food, ginger benefits the body in several ways, including enhancing mental performance. Ginger is available in various forms, ie juice, powder, capsules and as fresh rhizomes. The great health benefits of ginger make it a great addition to almost every meal. The health benefits of ginger include;
Ginger as a powerful antioxidant
Ginger is rich in antioxidants. Antioxidants play an important role in neutralizing free radicals. The body’s antioxidative defense system balances free radical production. Oxidative stress occurs if changes occur between the generation of reactive oxygen species and their neutralization by the antioxidant defense. In addition, ginger plays an essential role in reducing lipid oxidation and preventing the pathogenesis of diseases. 6-Dehydroshogaol, 6-shogaol and 1-dehydro-6-gingerdione are inhibitors of nitric oxide synthesis in activated macrophages. 6-chogaol has strong antioxidant properties due to the presence of an unsaturated ketone moiety.
Inflammation is a complex immune process, involving various mediators such as interleukin-1, tumor necrosis factor and anti-inflammatory cytokines. Ginger oil greatly reduces inflammation, especially joint inflammation. Also, ginger extracts suppress the synthesis of pro-inflammatory cytokines and play an important role in inhibiting cyclooxygenase and 5-lipoxygenase, which are essential for arachidonate metabolism, and reduce the induction of inflammatory genes.
Ginger extracts inhibit tumor development through tumor suppressor gene upregulation, induction of apoptosis and inactivation of vascular endothelial growth factor pathways. Tumor development and progression involves several steps including genetic and metabolic changes. 6-gingerol suppresses transformation, hyperproliferation, and inflammatory processes involved in various stages of carcinogenesis, angiogenesis, and metastasis. In addition, ginger constituents induce apoptosis in the LnCaP prostate cancer cell line by increasing the expression of tumor suppressor p53 and Bax and also decreasing the expression of Bcl-2. 6-sogaol is effective against breast cancer by inhibiting cell invasion and reducing the expression of matrix metalloproteinase-9. On the other hand, 6-gingerol promotes apoptosis through the maintenance of NAG-1 and G1 cell cycle arrest through the down-regulation of cyclin D1.
Ginger root extracts and gingerol inhibit the growth of Helicobacter pylori CagA+ strains, which have a specific gene, linked to the development of premalignant and malignant gastric lesions. 6-sogaol induces apoptosis in human colorectal carcinoma cells through the production of reactive oxygen species and activation of caspase-31, and 6-gingerol inhibits lung metastasis by B16F10 melanoma cells through activation of CD8+ T cells. 6-gingerol has an anti-tumor activity through the introduction of reactive oxygen species, which also promotes the activation of the tumor suppressor p53 and the arrest of the cell cycle and apoptosis.
Ethanol extract, of ginger, prevents microbial growth. Ginger has antimicrobial activity against E. coli, Salmonella typhi, and Bacillus subtilis. Gingerol and shagelol are active agents. The ethanolic extract of ginger powder and gingerol effectively inhibits Candida albicans. 6-gingerol and 12-gingerol, from ginger rhizome, are active against periodontal bacteria. 10-gingerol is an active inhibitor of Mycobacterium avium and M. tuberculosis.
Diabetes is a metabolic disorder resulting from abnormalities in carbohydrate metabolism due to low levels of insulin in the blood or insensitivity of target organs to insulin. Ginger and its constituents are effective in controlling diabetes and its complications through an anti-hyperglycemic effect. Ginger works by inhibiting oxidative stress and anti-inflammatory processes, although the exact mechanism is unknown.
The phenolic and flavonoid compounds in ginger act as powerful neuro-protectors. 6-sogaol has neuroprotective effects in transient global ischemia through inhibition of microglia. In addition, it shows a neuroprotective effect by accelerating the brain’s anti-oxidant defense mechanisms and reducing MDA levels to normal levels.
The effect on osteoarthritis
Ginger is useful in treating osteoarthritis, one of the main causes of severe musculoskeletal pain and disability. Pure and normal ginger extract significantly reduces the symptoms of osteoarthritis of the knee. Also, ginger is effective in relieving the symptoms of osteoarthritis with very few side effects. It works in the same way as Indomethacin.
Active compounds in ginger play a stimulating role in preventing ulcers. The compounds increase mucin secretion. 6-gingerol and 6-sogaol compounds are effective in stopping gastric contractions. Anti-emetic effect Ginger and its constituents show a significant effect on nausea and vomiting.
Carbon tetrachloride, mancozeb, acetamophine, and lead are among the important substances that poison the liver. Ginger is effective in preventing hepatotoxicity caused by these chemicals.
The effect on migraine
Ginger powder is very effective in suppressing migraines in a dose of 550 mg every 4 hours for five days.
The effect on the eye
Ginger and its constituents are effective in managing retinopathy, a symptom of diabetes.
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